Molecular cloning and functional expression of a new aphid isoprenyl diphosphate synthase
نویسندگان
چکیده
Aphids are important insect pests in temperate regions, damaging crop plants by sucking nutrients from the phloem and by transmitting plant viruses [1]. Chemical control of certain aphid species is becoming extremely difficult due to resistance to insecticides [2]. In this context, the development of novel pest control products that specifically target aphids is highly desirable. To this end, we decided to focus on aphid isoprenyl diphosphate synthases (IPPS) as potential biorational target sites. Short-chain E-IPPSs are a class of prenyltransferases that are central to isoprenoid metabolism. This group includes geranyl diphosphate synthase (GPPS), farnesyl diphosphate synthase (FPPS) and geranylgeranyl diphosphate synthase (GGPPS) which synthesize geranyl diphosphate (C10), farnesyl diphosphate (C15), and geranylgeranyl diphosphate (C20), respectively.
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